Superiority of the ear pinna over muscle tissue as site for DNA vaccination

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Ear Pinna: A Privileged DNA Electroporation Site for Inducing Strong Th1 Immune Responses

DNA vaccination appears a very attractive approach for inducing immune responses towards the encoded antigen, but studies in large animals and in humans revealed weaknesses of such responses. In this study, we evaluated a new approach based on a new device combining DNA vaccination with electroporation (EP) at the ear pinna site. Under optimal EP conditions, the expression of the DNA encoded an...

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ژورنال

عنوان ژورنال: Gene Therapy

سال: 1998

ISSN: 0969-7128,1476-5462

DOI: 10.1038/sj.gt.3300628